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Structure of 137638-05-2
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Methyl 3-cyclobutyl-3-oxopropanoate features a cyclobutyl group flanking a β-keto ester motif, delivering enhanced stability and reactivity in synthetic transformations. This bench-stable compound integrates readily into complex molecular architectures, particularly in the construction of strained ring systems and functionalized heterocycles under standard conditions.
Methyl 3-cyclobutyl-3-oxopropanoate serves as a versatile building block for cyclobutane-containing scaffolds, enabling efficient access to functionalized heterocycles via Michael additions and aldol-type condensations. The α,β-unsaturated ester functionality facilitates conjugate addition reactions with amines, thiols, and carbon nucleophiles, while the cyclobutyl ring imparts conformational rigidity beneficial in medicinal chemistry. Bench-stable and readily purified by flash chromatography, it functions as a practical intermediate in complex molecule synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H315-H319-H335
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Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501
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Lot numbers can be found on the outside label of a product: