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Structure of 13771-75-0
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5-Chlorobenzo[b]thiophene-2-carboxylic acid features a fused heterocyclic core with a chlorinated benzene ring and a carboxylic acid functional group at the 2-position. This electron-deficient scaffold integrates readily into pharmaceutical intermediates, enabling efficient coupling reactions under standard conditions. The molecule exhibits enhanced solubility in polar organic solvents and maintains stability during routine synthetic manipulations.
5-Chlorobenzo[b]thiophene-2-carboxylic acid serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the carboxylic acid and chloro positions. Its structural rigidity and electron-withdrawing substituents facilitate coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig transformations, with predictable regiochemistry. The compound exhibits good bench stability and is compatible with standard purification methods, making it suitable for medicinal chemistry campaigns and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: