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N,N-dimethyl-1-(piperidin-4-yl)methanamine

  • CAS No. 138022-00-1

  • Cat. No. CS-0463318
  • Purity≥98%
  • MDL No.MFCD05215181

*For research and further manufacturing use only, not for direct human use.

N,N-dimethyl-1-(piperidin-4-yl)methanamine|CS-0463318

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General Information

  • CAS No. 138022-00-1
  • Cat. No. CS-0463318
  • Purity ≥98%
  • MDL No. MFCD05215181
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₈N₂
  • Molecular Weight 142.24
  • Synonym(s) N,N-Dimethyl-1-piperidin-4-ylmethylamine
  • SMILES CN(C)CC1CCNCC1

Description

N,N-dimethyl-1-(piperidin-4-yl)methanamine features a tertiary amine core with enhanced solubility and basicity, enabling efficient coupling in synthetic transformations. The piperidine ring imparts conformational rigidity and favorable pharmacokinetic properties, while the dimethylamino group enhances nucleophilicity. This compound serves as a key building block in medicinal chemistry for constructing bioactive scaffolds.

Application

N,N-dimethyl-1-(piperidin-4-yl)methanamine serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient construction of nitrogen-containing scaffolds. Its tertiary amine and piperidine functionalities provide excellent solubility, functional group tolerance, and compatibility with standard coupling and reductive amination protocols. The molecule exhibits robust bench stability and facilitates straightforward purification, making it well-suited for high-throughput synthesis and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   0.5476
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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