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Structure of 1380500-88-8
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Methyltetrazine-acid delivers a reactive handle for bioconjugation, combining a methyl-substituted tetrazine ring with a carboxylic acid functionality. This pairing enables efficient inverse electron-demand Diels-Alder reactions with trans-cyclooctene derivatives, while the acid group supports direct coupling to amines or derivatization via standard peptide synthesis protocols. The molecule exhibits enhanced stability under physiological conditions and maintains high reactivity in aqueous environments.
Methyltetrazine-acid serves as a reliable bioorthogonal handle for site-specific conjugation in complex molecular systems. Its acid-functionalized tetrazine moiety enables efficient inverse electron-demand Diels-Alder (IEDDA) reactions with trans-cyclooctene (TCO) derivatives under physiological conditions. The methyl-substituted tetrazine enhances stability and reaction kinetics, while the carboxylic acid group facilitates purification and derivatization via standard amide coupling protocols. This dual-functional architecture supports modular synthesis of antibody-drug conjugates, protein probes, and functionalized polymers with high selectivity and minimal background labeling.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H315-H319-H332-H335
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Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P304+P341-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P363-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: