(2S,5S)-2,5-Dimethylpyrrolidine hydrochloride

Name: (2S,5S)-2,5-Dimethylpyrrolidine hydrochloride
Brand: ChemScene
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CAS No. 138133-34-3
Cat. No. CS-0111295
Purity≥98%
MDL No.MFCD24368644

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(2S,5S)-2,5-Dimethylpyrrolidine hydrochloride|CS-0111295

Structure of 138133-34-3

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Description

(2S,5S)-2,5-Dimethylpyrrolidine hydrochloride features a rigid, chiral pyrrolidine core with defined stereochemistry at the 2- and 5-positions, enhancing conformational control in asymmetric synthesis. The hydrochloride salt form ensures high solubility and stability under standard conditions, enabling reliable use in catalytic systems and medicinal chemistry applications.

Application

(2S,5S)-2,5-Dimethylpyrrolidine hydrochloride serves as a chiral building block for the synthesis of bioactive molecules and medicinal intermediates. Its rigid, enantiopure pyrrolidine core provides defined stereochemistry and enhances binding affinity in target-directed syntheses. The hydrochloride salt ensures excellent bench stability, ease of handling, and solubility in common organic solvents. It functions reliably in amine coupling reactions, reductive amination protocols, and as a scaffold for heterocyclic ring elaboration in pharmaceutical development.

General Information

CAS No. 138133-34-3
Cat. No. CS-0111295
Purity ≥98%
MDL No. MFCD24368644
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₄ClN
Molecular Weight 135.64
Synonym(s) (2S-trans)-2,5-DiMethylpyrrolidine Hydrochloride
SMILES C[C@H]1CC[C@H](C)N1.[H]Cl

Computational Chemistry Data

TPSA 12.03
LogP 1.5686
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(2S,5S)-2,5-Dimethylpyrrolidine hydrochloride

CAS No. 138133-34-3

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