tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

Name: tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate
Brand: ChemScene
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CAS No. 138227-63-1
Cat. No. CS-0154737
Purity≥95%
MDL No.MFCD04115023

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Type	HazMat Fee
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FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate|CS-0154737

Structure of 138227-63-1

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Description

tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate features a piperidine core linked to a para-aminophenoxy moiety, enabling direct incorporation into bioactive scaffolds. The tert-butyl ester group provides stability and facilitates deprotection under mild acidic conditions. This compound serves as a key intermediate in the synthesis of kinase inhibitors and CNS-targeted therapeutics.

Application

tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate serves as a versatile building block for the synthesis of bioactive heterocycles, enabling efficient construction of piperidine-based scaffolds through standard amine functionalization. The protected amine and phenoxy ether functionalities exhibit excellent bench stability and compatibility with diverse coupling reactions. Its ease of purification and predictable reactivity make it well-suited for medicinal chemistry campaigns requiring rapid access to analogues.

General Information

CAS No. 138227-63-1
Cat. No. CS-0154737
Purity ≥95%
MDL No. MFCD04115023
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₂₄N₂O₃
Molecular Weight 292.38
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1CCC(OC2=CC=C(N)C=C2)CC1

Computational Chemistry Data

TPSA 64.79
LogP 3.0471
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

CAS No. 138227-63-1

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