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Structure of 138274-14-3
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5-(Benzyloxy)-2-chloropyrimidine features a benzyl ether substituent at the 5-position, enhancing solubility and stability in organic media. The electron-deficient pyrimidine core supports efficient nucleophilic displacement reactions. This bench-stable compound serves as a key intermediate in the synthesis of kinase inhibitors and other bioactive heterocycles.
5-(Benzyloxy)-2-chloropyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient functionalization at the C5 position via palladium-catalyzed cross-coupling reactions. The benzyloxy group offers orthogonal protection and facilitates downstream deprotection under mild hydrogenolysis conditions. Its stability under standard reaction protocols and compatibility with diverse nucleophiles make it well-suited for constructing substituted pyrimidine scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: