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CS-W001157 4
Total: USD 88.00

2-(Tetrahydrofuran-3-yl)acetic acid

  • CAS No. 138498-97-2

  • Cat. No. CS-W005250
  • Molecule weight130.14
  • Purity≥95%
  • MDL No.MFCD06411265

*For research and further manufacturing use only, not for direct human use.

2-(Tetrahydrofuran-3-yl)acetic acid|CS-W005250

Structure of 138498-97-2

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General Information

  • CAS No. 138498-97-2
  • Cat. No. CS-W005250
  • Purity ≥95%
  • MDL No. MFCD06411265
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₃
  • Molecular Weight 130.14
  • Synonym(s) TETRAHYDRO-3-FURANYLACETICACID
  • SMILES O1CCC(C1)CC(=O)O

Description

2-(Tetrahydrofuran-3-yl)acetic acid features a tetrahydrofuran ring tethered to a carboxylic acid-bearing acetyl side chain, combining heterocyclic rigidity with reactive functionality. This structure enables integration into chiral building blocks and bioactive molecule scaffolds, offering enhanced solubility and metabolic stability in synthetic pathways.

Application

2-(Tetrahydrofuran-3-yl)acetic acid serves as a versatile chiral building block in synthetic organic chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its tetrahydrofuran ring imparts conformational rigidity and metabolic stability, while the carboxylic acid group facilitates direct derivatization or coupling reactions. The molecule exhibits excellent bench stability, compatibility with standard protecting group strategies, and ease of purification—making it well-suited for iterative synthesis and scale-up applications in medicinal chemistry workflows.

Synthesis

  • Route1
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      138498-96-1
    • ~%
    • In-stock
      2-(Tetrahydrofuran-3-yl)acetic acid|CS-W005250
      138498-97-2

    References

    • EP434365 A2, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   0.4976
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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