(S)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

Name: (S)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 138775-03-8
Cat. No. CS-0127816
Purity≥98%
MDL No.MFCD02179111

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(S)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid|CS-0127816

Structure of 138775-03-8

Size

Price

Quantity

* Please select Quantity before adding items.

Description

This chiral piperazine derivative features a (S)-configured backbone with orthogonal protecting groups: a benzyloxycarbonyl at the 4-position and a tert-butoxycarbonyl at the 1-position, enabling selective deprotection during peptide coupling. The carboxylic acid at the 2-position facilitates conjugation in synthetic sequences. Designed for modular assembly of bioactive scaffolds, this compound exhibits excellent stability under standard bench conditions and compatibility with diverse reaction environments.

Application

(S)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid serves as a versatile chiral building block for the synthesis of piperazine-based pharmaceutical intermediates. The protected piperazine core enables orthogonal functionalization, with the benzyloxycarbonyl and tert-butoxycarbonyl groups offering stable, orthogonal protection for amine and carboxylic acid functionalities. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient access to complex heterocyclic scaffolds in medicinal chemistry campaigns.

General Information

CAS No. 138775-03-8
Cat. No. CS-0127816
Purity ≥98%
MDL No. MFCD02179111
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₈H₂₄N₂O₆
Molecular Weight 364.39
Synonym(s) (S)-N-1-Boc-N-4-Cbz-2-piperazinecarboxylic acid
SMILES O=C([C@H]1N(C(OC(C)(C)C)=O)CCN(C(OCC2=CC=CC=C2)=O)C1)O

Computational Chemistry Data

TPSA 96.38
LogP 2.3291
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

138775-03-8 sigma138775-03-8 manufacturer138775-03-8 price138775-03-8 structure138775-03-8 SDSbuy 138775-03-8138775-03-8 supplier138775-03-8 uses138775-03-8 molecular weightprice of 138775-03-8138775-03-8 chemical name formula of 138775-03-8

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

(S)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid

CAS No. 138775-03-8

Recommended Products