4-Chloro-3-nitroaniline

Name: 4-Chloro-3-nitroaniline
Brand: ChemScene
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CAS No. 635-22-3
Cat. No. CS-W017580
Purity≥98%
MDL No.MFCD00007844

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 635-22-3

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Description

4-Chloro-3-nitroaniline features a chlorinated aryl ring paired with adjacent nitro and amino groups, creating a versatile scaffold for pharmaceutical intermediates. The electron-deficient aromatic core enables efficient coupling reactions, while the ortho-nitro group enhances reactivity in transition-metal-catalyzed transformations. This compound demonstrates robust stability under standard handling conditions.

Application

4-Chloro-3-nitroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation into heterocyclic scaffolds via nucleophilic substitution or subsequent reduction. Its ortho-chloro and meta-nitro groups provide complementary reactivity for sequential functionalization, with the nitro group readily reduced to an amine under standard conditions. Bench-stable and compatible with common purification methods, it facilitates efficient access to substituted anilines and complex molecular architectures.

General Information

CAS No. 635-22-3
Cat. No. CS-W017580
Purity ≥98%
MDL No. MFCD00007844
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClN₂O₂
Molecular Weight 172.57
Synonym(s) 4-chloro-3-nitro aniline
SMILES NC1=CC=C(Cl)C([N+]([O-])=O)=C1

Computational Chemistry Data

TPSA 69.16
LogP 1.8304
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS06,GHS08,GHS09
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H300+H310+H330-H315-H319-H373-H411
Precautionary Statements : P260-P262-P264-P270-P271-P273-P280-P284-P302+P352-P304+P340-P330-P361-P391-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Chloro-3-nitroaniline

CAS No. 635-22-3

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