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Structure of 1389329-66-1
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This chiral phosphine amine features a rigid, octahydrodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin scaffold with defined (11bR) and (R)-1-phenylethyl stereochemistry. The bis(1-phenylethyl) substitution pattern imparts steric bulk and enhanced configurational stability, while the tertiary amine moiety enables facile protonation and coordination to transition metals. Designed for asymmetric catalysis, this ligand integrates robustness with high enantioselectivity in Pd- and Ni-catalyzed cross-coupling reactions under standard conditions.
(11bR)-N,N-bis((R)-1-phenylethyl)-8,9,10,11,12,13,14,15-octahydrodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine serves as a chiral phosphine ligand featuring a rigid, polycyclic backbone with tunable steric bulk from the (R)-1-phenylethyl groups. It facilitates asymmetric transition-metal-catalyzed transformations, particularly in palladium- and nickel-mediated cross-couplings, offering enhanced enantioselectivity and stability under air compared to common monodentate phosphines. Its bench-stable nature and ease of purification support reliable application in catalytic process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: