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Structure of 1392212-91-7
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8-(Trifluoromethyl)chroman-4-amine hydrochloride features a trifluoromethyl group at the 8-position of a chroman scaffold, imparting enhanced electron-withdrawing character and metabolic stability. The amine functionality enables facile derivatization, while the hydrochloride salt ensures high solubility and crystalline handling. This compound serves as a key building block for bioactive molecules in medicinal chemistry, particularly in kinase inhibitor and CNS-targeted drug discovery.
8-(Trifluoromethyl)chroman-4-amine hydrochloride serves as a versatile building block for medicinal chemistry, enabling the synthesis of chroman-based scaffolds with enhanced metabolic stability and lipophilicity. The trifluoromethyl group imparts strong electron-withdrawing character and improved membrane permeability, while the amine functionality facilitates downstream derivatization via coupling reactions. Bench-stable and readily purified by recrystallization, it functions effectively in standard amide bond formation, reductive amination, and heterocycle functionalization protocols common in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: