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CS-W001157 4
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2-Bromo-2',4',6'-triisopropyl-3,6-dimethoxy-1,1'-biphenyl

  • CAS No. 1402393-56-9

  • Cat. No. CS-0202163
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-2',4',6'-triisopropyl-3,6-dimethoxy-1,1'-biphenyl|CS-0202163

Structure of 1402393-56-9

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General Information

  • CAS No. 1402393-56-9
  • Cat. No. CS-0202163
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₃₁BrO₂
  • Molecular Weight 419.40
  • Synonym(s) 2-bromo-3,6-dimethoxy-2',4',6'-tris(isopropyl)-1,1'-biphenyl
  • SMILES BrC1=C(C2=C(C(C)C)C=C(C(C)C)C=C2C(C)C)C(OC)=CC=C1OC

Description

This sterically encumbered biphenyl features three isopropyl groups and two methoxy substituents that enhance solubility and stability under standard conditions. The bromine atom enables efficient cross-coupling reactions, while the electron-donating methoxy groups facilitate selective functionalization in catalytic transformations.

Application

2-Bromo-2',4',6'-triisopropyl-3,6-dimethoxy-1,1'-biphenyl serves as a sterically hindered, electron-rich aryl bromide enabling efficient Suzuki-Miyaura coupling under mild conditions. The triisopropyl and dimethoxy substituents enhance solubility and stability while minimizing undesired side reactions. Functions effectively as a building block for complex biaryl scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   7.5035
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   6

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