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CS-W001157 4
Total: USD 88.00

1-Cyclopropyl-1H-pyrazole-3-carboxylic acid

  • CAS No. 1403333-94-7

  • Cat. No. CS-0052579
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Cyclopropyl-1H-pyrazole-3-carboxylic acid|CS-0052579

Structure of 1403333-94-7

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General Information

  • CAS No. 1403333-94-7
  • Cat. No. CS-0052579
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O₂
  • Molecular Weight 152.15
  • Synonym(s) None
  • SMILES OC(=O)C1=NN(C=C1)C1CC1

Description

1-Cyclopropyl-1H-pyrazole-3-carboxylic acid features a rigid pyrazole core with a cyclopropyl substituent at the 1-position, enhancing lipophilicity and metabolic stability. The carboxylic acid group enables direct conjugation or derivatization in medicinal chemistry campaigns. This scaffold integrates readily into bioactive molecules requiring moderate polarity and defined spatial orientation.

Application

1-Cyclopropyl-1H-pyrazole-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its pyrazole core exhibits favorable metabolic stability and moderate lipophilicity, while the carboxylic acid functionality facilitates direct coupling reactions or derivatization for salt formation. The cyclopropyl group enhances conformational rigidity and modulates physicochemical properties, supporting efficient synthesis and purification in multi-step routes.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   0.9162
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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