4-Chloro-2-fluorobenzenesulfonyl chloride

Name: 4-Chloro-2-fluorobenzenesulfonyl chloride
Brand: ChemScene
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CAS No. 141337-26-0
Cat. No. CS-0157094
Molecule weight229.06
Purity≥96%
MDL No.MFCD03094560

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Chloro-2-fluorobenzenesulfonyl chloride|CS-0157094

Structure of 141337-26-0

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General Information

CAS No. 141337-26-0
Cat. No. CS-0157094
Purity ≥96%
MDL No. MFCD03094560
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃Cl₂FO₂S
Molecular Weight 229.06
Synonym(s) 4-Chloro-2-fluorobenzenesulphonyl chloride
SMILES C1=CC(=C(C=C1Cl)F)S(=O)(=O)Cl

Description

4-Chloro-2-fluorobenzenesulfonyl chloride features a dual halogenated aromatic core that enhances electrophilic reactivity while maintaining stability under standard handling conditions. This sulfonyl chloride derivative facilitates efficient coupling reactions in synthetic routes to fluorinated sulfonamides and pharmaceutical intermediates, offering predictable regioselectivity due to the ortho-fluoro, para-chloro substitution pattern.

Application

4-Chloro-2-fluorobenzenesulfonyl chloride serves as a versatile electrophilic sulfonylating agent, enabling efficient introduction of the sulfonyl group under mild conditions. Its reactivity is enhanced by the electron-withdrawing chloro and fluoro substituents, which stabilize the sulfonamide product and facilitate nucleophilic substitution with amines and alcohols. The compound exhibits good bench stability and enables straightforward purification, making it well-suited for use in the synthesis of sulfonamide-based pharmaceutical intermediates and functionalized heterocycles.

Synthesis

Route1
- In-stock
  
  57946-56-2
- ~73%
- In-stock
  
  141337-26-0
References
- Schering Corporation Patent: US2003/232859 A1, 2003 ; Location in patent: Page 56 ; US 20030232859 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 34.14
LogP 2.4066
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Chloro-2-fluorobenzenesulfonyl chloride

CAS No. 141337-26-0

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