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Structure of 141412-60-4
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2,5-Difluoro-4-nitrotoluene features a trifunctional aromatic core with two fluorine atoms and a nitro group positioned for orthogonal reactivity. This electron-deficient scaffold enables direct coupling in cross-coupling protocols and serves as a key intermediate in the synthesis of pharmaceuticals and agrochemicals. The molecule exhibits enhanced stability under standard conditions and facilitates selective functionalization at the methyl position.
2,5-Difluoro-4-nitrotoluene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to fluorinated aromatic scaffolds. Its complementary reactivity profile—where the nitro group facilitates electrophilic substitution and the methyl group permits oxidation or functionalization—supports diverse downstream transformations. Bench-stable and readily purified by recrystallization, it functions effectively in standard coupling reactions and heterocycle formation protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: