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CS-W001157 4
Total: USD 88.00

2-(Methylsulfonyl)pyrimidine

  • CAS No. 14161-09-2

  • Cat. No. CS-0150134
  • Purity≥98%
  • MDL No.MFCD06795939

*For research and further manufacturing use only, not for direct human use.

2-(Methylsulfonyl)pyrimidine|CS-0150134

Structure of 14161-09-2

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General Information

  • CAS No. 14161-09-2
  • Cat. No. CS-0150134
  • Purity ≥98%
  • MDL No. MFCD06795939
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆N₂O₂S
  • Molecular Weight 158.18
  • Synonym(s) Methyl pyrimidin-2-yl sulphone
  • SMILES CS(=O)(=O)C1=NC=CC=N1

Description

2-(Methylsulfonyl)pyrimidine features a polar, electron-withdrawing methylsulfonyl group attached to a pyrimidine core, enhancing solubility and metabolic stability. This combination enables robust integration into pharmaceutical scaffolds, particularly where improved pharmacokinetic profiles are required.

Application

2-(Methylsulfonyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C2 position of the pyrimidine core. Its methylsulfonyl group provides excellent stability and solubility while facilitating subsequent cross-coupling reactions. The compound exhibits high functional group tolerance and is compatible with standard synthetic workflows, making it a reliable scaffold for developing kinase inhibitors and other bioactive heterocycles.

Synthesis

  • Route1
    • 2-(Methylthio)pyrimidine|CS-0078682
      823-09-6
    • Sodium sulfate anhydrous, United States Pharmacopeia (USP) Reference Standard|CS-0909798
      7757-82-6
    • ~%
    • In-stock
      2-(Methylsulfonyl)pyrimidine|CS-0150134
      14161-09-2

    References

    • US4266058 A1, ;
  • Route2
    • 2-(Methylthio)pyrimidine|CS-0078682
      823-09-6
    • ~47%
    • In-stock
      2-(Methylsulfonyl)pyrimidine|CS-0150134
      14161-09-2

    References

    • Babaev; Ermolat'ev Russian Journal of General Chemistry, 2010 , vol. 80, # 12 p. 2572 - 2589

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.92
  • LogP   -0.1199
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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