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Structure of 1418130-40-1
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3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline features a boronate ester group flanked by electron-rich tetramethylcyclopentadienone rings, enabling stable coupling under mild conditions. The para-fluoro substitution enhances metabolic stability and modulates electronic properties. This bench-stable reagent integrates seamlessly into Suzuki-Miyaura cross-coupling workflows for constructing arylated heterocycles and bioactive scaffolds.
3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline serves as a versatile boron-containing building block for Suzuki-Miyaura cross-coupling reactions. The ortho-borylated aniline moiety enables efficient C–C bond formation under mild conditions, with excellent functional group tolerance and bench stability. Its tetramethyl-substituted dioxaborolane enhances reactivity and minimizes protodeboronation, facilitating reliable coupling in complex molecule synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: