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Structure of 142363-59-5
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3-Fluoroquinolin-8-ol features a fluorine atom at the 3-position and a hydroxyl group at the 8-position of the quinoline scaffold, delivering enhanced electron-withdrawing character and hydrogen-bonding capacity. This combination enables efficient integration into pharmaceutical intermediates and ligands for metal complexes.
3-Fluoroquinolin-8-ol serves as a versatile heterocyclic building block for medicinal chemistry and materials science, enabling direct functionalization at the C8 position via palladium-catalyzed cross-coupling. Its fluorinated quinoline core provides enhanced metabolic stability and modulates electronic properties, while the phenolic hydroxyl group facilitates derivatization through etherification or metal coordination. Bench-stable and amenable to standard purification methods, it functions effectively in multi-step syntheses of kinase inhibitors and photoluminescent scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: