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Structure of 1427324-78-4
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5-Fluorobenzofuran-6-carbonitrile features a fluorinated benzofuran core with a nitrile group at the 6-position, enabling integration into diverse heterocyclic architectures. This electron-deficient scaffold supports efficient coupling reactions and serves as a key building block in medicinal chemistry and materials science.
5-Fluorobenzofuran-6-carbonitrile serves as a versatile building block for the synthesis of fluorinated heterocyclic scaffolds. The nitrile group enables diverse transformations including hydrolysis to carboxylic acids, reduction to aldehydes or amines, and participation in cycloaddition reactions. Its benzofuran core provides structural rigidity and enhanced metabolic stability, making it valuable in medicinal chemistry lead optimization. Bench-stable and readily purified by recrystallization, it functions effectively in standard coupling protocols and transition-metal-catalyzed transformations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302+H312+H332-H315-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: