4-Bromopyrazolo[1,5-a]pyridine

Name: 4-Bromopyrazolo[1,5-a]pyridine
Brand: ChemScene
Availability: InStock
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CAS No. 1427404-87-2
Cat. No. CS-0102575
Purity≥97%
MDL No.MFCD23710563

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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4-Bromopyrazolo[1,5-a]pyridine|CS-0102575

Structure of 1427404-87-2

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Description

4-Bromopyrazolo[1,5-a]pyridine is a heterocyclic building block featuring a brominated pyrazolopyridine core. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions and serves as a key intermediate in the synthesis of bioactive compounds. The bromine substituent offers high reactivity under palladium-catalyzed conditions, facilitating efficient construction of complex molecular architectures.

Application

4-Bromopyrazolo[1,5-a]pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to construct biologically relevant heterocyclic architectures. The bromine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, while the pyrazolo[1,5-a]pyridine core offers excellent bench stability and compatibility with diverse functional groups. Its defined regiochemistry facilitates predictable transformation pathways in API synthesis and target-oriented compound libraries.

General Information

CAS No. 1427404-87-2
Cat. No. CS-0102575
Purity ≥97%
MDL No. MFCD23710563
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅BrN₂
Molecular Weight 197.03
Synonym(s) 4-Bromo-pyrazolo[1,5-a]pyridine
SMILES BrC1=CC=CN2C1=CC=N2

Computational Chemistry Data

TPSA 17.3
LogP 2.0968
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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4-Bromopyrazolo[1,5-a]pyridine

CAS No. 1427404-87-2

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