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CS-W001157 4
Total: USD 88.00

4-Fluoro-3-methoxyaniline

  • CAS No. 64465-53-8

  • Cat. No. CS-W005619
  • Molecule weightNone
  • Purity≥98%
  • MDL No.MFCD00665789

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-3-methoxyaniline|CS-W005619

Structure of 64465-53-8

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General Information

  • CAS No. 64465-53-8
  • Cat. No. CS-W005619
  • Purity ≥98%
  • MDL No. MFCD00665789
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FNO
  • Molecular Weight None
  • Synonym(s) 5-Amino-2-fluoroanisole
  • SMILES C1=C(C(=CC=C1N)F)OC

Description

4-Fluoro-3-methoxyaniline features a fluorinated aromatic ring bearing both methoxy and primary amine functionalities, enabling selective coupling in pharmaceutical synthesis. The electron-withdrawing fluorine at the para-position enhances reactivity in nucleophilic substitution processes. This bench-stable intermediate integrates readily into complex molecular architectures requiring directed functionalization.

Application

4-Fluoro-3-methoxyaniline serves as a valuable building block in medicinal chemistry, enabling access to fluorinated aromatic scaffolds via standard coupling reactions. Its ortho-fluoro and meta-methoxy substituents provide directional control in electrophilic substitution and facilitate downstream functionalization. The compound exhibits good bench stability and compatibility with common protecting group strategies, simplifying purification and integration into multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H318-H335-H412
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.4165
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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