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CS-W001157 4
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5-Methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzoic acid

  • CAS No. 1430738-03-6

  • Cat. No. CS-0096919
  • Molecule weight369.48
  • Purity≥98%
  • MDL No.MFCD33023604

*For research and further manufacturing use only, not for direct human use.

5-Methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzoic acid|CS-0096919

Structure of 1430738-03-6

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General Information

  • CAS No. 1430738-03-6
  • Cat. No. CS-0096919
  • Purity ≥98%
  • MDL No. MFCD33023604
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₇NO₆Si
  • Molecular Weight 369.48
  • Synonym(s) None
  • SMILES O=C(O)C1=CC(OC)=C(O[Si](C(C)C)(C(C)C)C(C)C)C=C1[N+]([O-])=O

Description

5-Methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzoic acid features a sterically shielded triisopropylsilyl ether that enhances stability and solubility in organic media. The electron-deficient aryl core, combined with a methoxy and nitro substituent, enables precise tuning of reactivity in cross-coupling and conjugation workflows. This bench-stable derivative facilitates efficient late-stage functionalization in complex molecule synthesis.

Application

5-Methoxy-2-nitro-4-((triisopropylsilyl)oxy)benzoic acid serves as a versatile building block for the synthesis of functionalized aromatic scaffolds. The triisopropylsilyl (TIPS) ether provides robust protection of the phenolic hydroxyl, enabling orthogonal manipulation in complex sequences. The nitro and carboxylic acid groups offer defined reactivity for downstream transformations, including reduction, coupling, and cyclization. Bench-stable and compatible with standard synthetic workflows, it facilitates efficient access to substituted heterocycles and bioactive intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   98.9
  • LogP   4.8559
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   8

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