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1,4-Dimethoxybut-2-yne

  • CAS No. 16356-02-8

  • Cat. No. CS-0181843
  • Molecule weight114.14
  • Purity≥97%
  • MDL No.MFCD00048069

*For research and further manufacturing use only, not for direct human use.

1,4-Dimethoxybut-2-yne|CS-0181843

Structure of 16356-02-8

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General Information

  • CAS No. 16356-02-8
  • Cat. No. CS-0181843
  • Purity ≥97%
  • MDL No. MFCD00048069
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₂
  • Molecular Weight 114.14
  • Synonym(s) 1,4-Dimethoxy-2-butyne
  • SMILES COCC#CCOC

Description

1,4-Dimethoxybut-2-yne features two methoxy groups flanking a conjugated alkyne, delivering enhanced solubility and stability in polar solvents. This electron-rich scaffold enables efficient coupling reactions under mild conditions, serving as a key building block in synthetic organic chemistry and the construction of functionalized dienes.

Application

1,4-Dimethoxybut-2-yne serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted dienes and heterocyclic frameworks. Its conjugated alkyne functionality exhibits robust stability under standard bench conditions and demonstrates excellent tolerance to common functional groups. The molecule facilitates palladium-catalyzed coupling reactions and participates reliably in cycloaddition processes, offering predictable reactivity for the construction of complex molecular architectures in medicinal chemistry and materials synthesis.

Synthesis

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    • In-stock
      1,4-Dimethoxybut-2-yne|CS-0181843
      16356-02-8

    References

    • Adams, Harry; Anderson, James C.; Bell, Richard; Jones, D. Neville; Peel, Michael R.; Tomkinson, Nicholas C. O. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 23 p. 3967 - 3973
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      18857-03-9
    • In-stock
      1,4-Dimethoxybut-2-yne|CS-0181843
      16356-02-8

    References

    • Hennion; Kupiecki Journal of Organic Chemistry, 1953 , vol. 18, p. 1601,1606 Full Text Show Details Ichikizaki et al. Bulletin of the Chemical Society of Japan, 1955 , vol. 28, p. 80,82
  • Route3
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      186581-53-3
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      110-65-6
    • ~%
    • In-stock
      1,4-Dimethoxybut-2-yne|CS-0181843
      16356-02-8

    References

    • Mueller et al. Zeitschrift fuer Naturforschung, 1959 , vol. 14b, p. 209

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 3271
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   0.2826
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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