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CS-W001157 4
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Ethyl 2-(3-chloropropoxy)acetate

  • CAS No. 143165-48-4

  • Cat. No. CS-0163231
  • Purity≥96%
  • MDL No.MFCD20621873

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(3-chloropropoxy)acetate|CS-0163231

Structure of 143165-48-4

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General Information

  • CAS No. 143165-48-4
  • Cat. No. CS-0163231
  • Purity ≥96%
  • MDL No. MFCD20621873
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃ClO₃
  • Molecular Weight 180.63
  • Synonym(s) None
  • SMILES O=C(OCC)COCCCCl

Description

Ethyl 2-(3-chloropropoxy)acetate features a chlorinated aliphatic chain appended to an ester-functionalized acetic acid scaffold. This electrophilic ether moiety enables efficient coupling in nucleophilic substitution reactions, particularly in the synthesis of bioactive heterocycles and pharmaceutical intermediates. The molecule exhibits good stability under standard bench conditions and facilitates straightforward derivatization.

Application

Ethyl 2-(3-chloropropoxy)acetate serves as a versatile bifunctional building block for the synthesis of bioactive molecules and heterocyclic scaffolds. Its chloroalkoxy functionality enables efficient nucleophilic displacement reactions, while the ester group supports selective transformations under standard conditions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development workflows.

Synthesis

  • Route1
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    • ~75%
    • In-stock
      Ethyl 2-(3-chloropropoxy)acetate|CS-0163231
      143165-48-4

    References

    • Buchanan; Gerzain; Bensimon; Ellen; Reynolds Journal of Molecular Structure, 1997 , vol. 404, # 3 p. 307 - 317 Title/Abstract Full Text View citing articles Show Details Buchanan; Gerzain; Bourque Magnetic Resonance in Chemistry, 1997 , vol. 35, # 5 p. 283 - 289

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   1.195
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   6

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