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6-Chloro-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine

  • CAS No. 1431720-68-1

  • Cat. No. CS-0080512
  • Molecule weight221.57
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Chloro-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine|CS-0080512

Structure of 1431720-68-1

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General Information

  • CAS No. 1431720-68-1
  • Cat. No. CS-0080512
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃ClF₃N₃
  • Molecular Weight 221.57
  • Synonym(s) None
  • SMILES ClC1=CC(NN=C2C(F)(F)F)=C2C=N1

Description

6-Chloro-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine is a heterocyclic scaffold featuring a chlorinated pyrazolopyridine core with a trifluoromethyl group at the 3-position. This electron-deficient system enables efficient coupling in cross-coupling reactions and serves as a key building block in medicinal chemistry for targeted drug discovery.

Application

6-Chloro-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine serves as a versatile heterocyclic building block for medicinal chemistry and agrochemical research. Its electron-deficient pyrazolopyridine core enables efficient Suzuki-Miyaura and Buchwald-Hartwig couplings, while the chloro and trifluoromethyl groups offer orthogonal reactivity for downstream functionalization. Bench-stable and compatible with standard purification methods, it facilitates rapid scaffold diversification in target-oriented synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301+H311+H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   2.6301
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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