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Structure of 1434141-81-7
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tert-Butyl 3,3-difluoro-4-hydroxypyrrolidine-1-carboxylate features a sterically shielded pyrrolidine core with dual fluorine atoms at the 3-position, enhancing metabolic stability and lipophilicity. The pendant hydroxyl group enables direct derivatization or protection, while the tert-butyl ester facilitates straightforward deprotection under mild acidic conditions. This scaffold integrates seamlessly into bioactive molecule design for medicinal chemistry applications.
tert-Butyl 3,3-difluoro-4-hydroxypyrrolidine-1-carboxylate serves as a versatile building block for fluorinated pyrrolidine scaffolds in medicinal chemistry. The difluoro substitution at C3 enhances metabolic stability and modulates basicity, while the hydroxyl group enables downstream functionalization via oxidation, protection, or coupling reactions. Its tert-butyl carbamate moiety offers excellent bench stability and simplifies purification, facilitating integration into multi-step syntheses of bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362
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Lot numbers can be found on the outside label of a product: