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Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate

  • CAS No. 144164-11-4

  • Cat. No. CS-0149754
  • Purity≥95%
  • MDL No.MFCD07367634

*For research and further manufacturing use only, not for direct human use.

Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate|CS-0149754

Structure of 144164-11-4

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General Information

  • CAS No. 144164-11-4
  • Cat. No. CS-0149754
  • Purity ≥95%
  • MDL No. MFCD07367634
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₂₇N₃O₃S
  • Molecular Weight 425.54
  • Synonym(s) thiazol-5-ylmethyl (2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-ylcarbamate
  • SMILES O=C(OCC1=CN=CS1)N[C@@H](CC2=CC=CC=C2)[C@@H](O)C[C@@H](N)CC3=CC=CC=C3

Synthesis

  • Route1
    • tert-Butyl (thiazol-5-ylmethyl) ((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate Ritonavir Impurity|CS-0437853
      162849-95-8
    • ~96%
    • Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate|CS-0149754
      144164-11-4

    References

    • ABBOTT LABORATORIES Patent: WO2008/27932 A2, 2008 ; Location in patent: Page/Page column 96 ; WO 2008/027932 A2
  • Route2
    • null|null
      144163-44-0
    • In-stock
      4-Nitrophenyl (thiazol-5-ylmethyl) carbonate|CS-0157448
      144163-97-3
    • ~15%
    • Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate|CS-0149754
      144164-11-4

    References

    • Abbott Laboratories Patent: US5559158 A1, 1996 ;
  • Route3

    References

    • Abbott Laboratories Patent: US5559158 A1, 1996 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   97.47
  • LogP   3.3016
  • H_Acceptors   6
  • H_Donors   3
  • Rotatable_Bonds   10

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