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CS-W001157 4
Total: USD 88.00

cis-3,5-Dimethylpiperidine

  • CAS No. 14446-75-4

  • Cat. No. CS-0139658
  • Molecule weight113.20
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

cis-3,5-Dimethylpiperidine|CS-0139658

Structure of 14446-75-4

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General Information

  • CAS No. 14446-75-4
  • Cat. No. CS-0139658
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅N
  • Molecular Weight 113.20
  • Synonym(s) cis-3,5-Lupetidine
  • SMILES C[C@H]1C[C@@H](C)CNC1

Description

cis-3,5-Dimethylpiperidine is a sterically hindered, bench-stable piperidine derivative featuring two methyl groups at the 3 and 5 positions in a cis configuration. This stereochemistry enhances conformational rigidity and influences basicity, making it valuable for asymmetric synthesis and as a chiral auxiliary in medicinal chemistry applications.

Application

cis-3,5-Dimethylpiperidine serves as a valuable chiral building block in medicinal chemistry, offering enhanced metabolic stability and defined stereochemistry for drug discovery applications. Its constrained conformation facilitates target engagement in GPCR and kinase modulators. The molecule exhibits excellent bench stability, compatibility with diverse functional groups, and enables straightforward incorporation into complex scaffolds via standard alkylation or reductive amination protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225
Precautionary Statements : P210-P243-P273

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.2519
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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