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Structure of 1446481-36-2
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This pyrazole boronate ester integrates a fluoromethyl group and a tetramethyl-1,3,2-dioxaborolane moiety, enabling efficient cross-coupling under mild conditions. The electron-deficient pyrazole core enhances reactivity in Suzuki-Miyaura transformations, while the stable boronate functionality ensures reliable handling and compatibility with diverse reaction setups.
1-(Fluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The fluoromethyl group enables direct functionalization and metabolic stabilization in medicinal chemistry applications. The pinacol boronate moiety offers excellent bench stability, mild reaction conditions, and broad functional group tolerance, facilitating efficient C–C bond formation with aryl, heteroaryl, and vinyl halides. This compound functions reliably in late-stage diversification and scaffold elaboration workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: