(2-Chlorothiazol-5-yl)methanol

Name: (2-Chlorothiazol-5-yl)methanol
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 145015-15-2
Cat. No. CS-0067979
Purity≥95%
MDL No.MFCD03001277

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(2-Chlorothiazol-5-yl)methanol|CS-0067979

Structure of 145015-15-2

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General Information

CAS No. 145015-15-2
Cat. No. CS-0067979
Purity ≥95%
MDL No. MFCD03001277
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₄ClNOS
Molecular Weight 149.60
Synonym(s) (2-Chloro-1,3-thiazol-5-yl)methanol
SMILES OCC1=CN=C(Cl)S1

Description

(2-Chlorothiazol-5-yl)methanol features a chlorinated thiazole core bearing a reactive hydroxymethyl group, enabling direct functionalization in synthetic routes. This bench-stable scaffold integrates readily into bioactive molecule frameworks, particularly where halogenated heterocycles enhance target affinity or metabolic stability.

Application

(2-Chlorothiazol-5-yl)methanol serves as a versatile building block for thiazole-based heterocycles, enabling efficient functionalization at the 5-position. Its benzylic-like alcohol functionality facilitates oxidation to the aldehyde or ester, and it participates reliably in coupling reactions with amines, nucleophiles, and transition metal catalysts. The chloro substituent provides orthogonal reactivity for palladium-catalyzed cross-coupling, supporting modular synthesis of bioactive scaffolds. Bench-stable and amenable to standard purification methods, it functions effectively in medicinal chemistry and process development workflows.

Synthesis

Route1
- In-stock
  
  95453-58-0
- ~83%
- In-stock
  
  145015-15-2
References
- ELI LILLY AND COMPANY Patent: WO2007/2181 A2, 2007 ; Location in patent: Page/Page column 142-143 ; WO 2007/002181 A2
Route2
- In-stock
  
  105827-91-6
- ~%
- In-stock
  
  145015-15-2
References
- US5959118 A1, ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 33.12
LogP 1.2888
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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(2-Chlorothiazol-5-yl)methanol

CAS No. 145015-15-2

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