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CS-W001157 4
Total: USD 88.00

2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE

  • CAS No. 95453-58-0

  • Cat. No. CS-W001048
  • Purity≥97%
  • MDL No.MFCD01568717

*For research and further manufacturing use only, not for direct human use.

2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE|CS-W001048

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General Information

  • CAS No. 95453-58-0
  • Cat. No. CS-W001048
  • Purity ≥97%
  • MDL No. MFCD01568717
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂ClNOS
  • Molecular Weight 147.58
  • Synonym(s) 5-Thiazolecarboxaldehyde, 2-chloro-
  • SMILES Clc1ncc(C=O)s1

Description

2-Chlorothiazole-5-carbaldehyde features a reactive aldehyde group fused to a chlorothiazole scaffold, enabling direct incorporation into heterocyclic architectures. This bench-stable, moisture-tolerant reagent facilitates efficient coupling reactions in medicinal chemistry and materials synthesis.

Application

2-Chlorothiazole-5-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to thiazole-based scaffolds through palladium-catalyzed cross-coupling and nucleophilic addition reactions. Its aldehyde functionality offers high reactivity toward hydrazines, amines, and organometallic reagents, while the chlorine substituent supports further functionalization via Suzuki or Buchwald–Hartwig coupling. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for modular synthesis workflows in API development.

Synthesis

  • Route1

    References

    • Fotouhi, Nader; Gillespie, Paul; Guthrie, Robert William; Pietranico-Cole, Sherrie Lynn; Yun, Weiya Patent: US2002/161237 A1, 2002 ;
  • Route2
    • In-stock
      2-Chlorothiazole|CS-D1169
      3034-52-4
    • null|null
      68-12-2
    • ~%
    • In-stock
      2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE|CS-W001048
      95453-58-0

    References

    • Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 2 p. 329 - 331

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.609
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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