4-Bromo-2-methoxybenzene-1-sulfonyl chloride

Name: 4-Bromo-2-methoxybenzene-1-sulfonyl chloride
Brand: ChemScene
Availability: InStock
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CAS No. 145915-29-3
Cat. No. CS-0308397
Molecule weight285.54
Purity≥97%
MDL No.MFCD11847575

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Bromo-2-methoxybenzene-1-sulfonyl chloride|CS-0308397

Structure of 145915-29-3

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General Information

CAS No. 145915-29-3
Cat. No. CS-0308397
Purity ≥97%
MDL No. MFCD11847575
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆BrClO₃S
Molecular Weight 285.54
Synonym(s) 4-Bromo-2-methoxybenzenesulfonyl chloride
SMILES COC1=C(C=CC(=C1)Br)S(=O)(=O)Cl

Description

4-Bromo-2-methoxybenzene-1-sulfonyl chloride features a bromine substituent and methoxy group positioned ortho to the sulfonyl chloride moiety, enabling selective functionalization in synthetic workflows. This electron-deficient aryl sulfonamide precursor facilitates efficient coupling reactions under mild conditions, offering enhanced stability and controlled reactivity for complex molecule assembly.

Application

4-Bromo-2-methoxybenzene-1-sulfonyl chloride serves as a versatile sulfonylating agent for the synthesis of sulfonamide derivatives. Its bromo and methoxy substituents enable further functionalization via cross-coupling or electrophilic substitution, while the reactive sulfonyl chloride group facilitates efficient amine coupling under mild conditions. The compound exhibits good bench stability and compatibility with diverse functional groups, making it suitable for iterative synthesis in medicinal chemistry and API development workflows.

Synthesis

Route1
- 2398-37-0
- ~%
- In-stock
  
  145915-29-3
References
- AGOURON PHARMACEUTICALS, INC. Patent: US2005/148631 A1, 2005 ; Location in patent: Page/Page column 32 ;
Route2
- 2398-37-0
- ~5%
- In-stock
  
  145915-29-3
- In-stock
  
  23095-16-1
References
- Bristol-Myers Squibb Co. Patent: US5514696 A1, 1996 ; US 5514696 A

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 43.37
LogP 2.3852
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Bromo-2-methoxybenzene-1-sulfonyl chloride

CAS No. 145915-29-3

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