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Structure of 1780-26-3
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4,6-Dichloro-2-methylpyrimidine serves as a pivotal heterocyclic scaffold in medicinal chemistry, featuring two chlorine substituents at electron-deficient positions and a methyl group that enhances regioselectivity. This configuration enables efficient coupling reactions in the synthesis of kinase inhibitors and nucleoside analogs, particularly under mild conditions. The compound exhibits excellent stability and solubility in common organic solvents, facilitating its integration into multi-step synthetic sequences.
4,6-Dichloro-2-methylpyrimidine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of pyrimidine-based scaffolds. Its dual chloro substituents at C4 and C6 facilitate nucleophilic substitution reactions under mild conditions, while the methyl group at C2 provides steric and electronic modulation. The compound exhibits good bench stability, compatibility with diverse functional groups, and ease of purification—key advantages for iterative synthesis and scale-up applications.
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GHS Pictogram :
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GHS No : GHS07,GHS09
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Signal Word : Warning
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UN#: 3077
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H302-H317-H411
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Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501
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Lot numbers can be found on the outside label of a product: