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CS-W001157 4
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Methyl 5-aminothiophene-2-carboxylate

  • CAS No. 14597-58-1

  • Cat. No. CS-W005967
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD07687259

*For research and further manufacturing use only, not for direct human use.

Methyl 5-aminothiophene-2-carboxylate|CS-W005967

Structure of 14597-58-1

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General Information

  • CAS No. 14597-58-1
  • Cat. No. CS-W005967
  • Purity ≥97%
  • MDL No. MFCD07687259
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₂S
  • Molecular Weight None
  • Synonym(s) 5-aminothiophene-2-carboxylic methyl ester
  • SMILES O=C(C1=CC=C(N)S1)OC

Description

Methyl 5-aminothiophene-2-carboxylate features a thiophene core bearing both amino and ester functionalities, enabling direct incorporation into heterocyclic scaffolds. The electron-donating amino group enhances reactivity at the 5-position, while the methyl ester facilitates downstream derivatization. This compound serves as a key intermediate in the synthesis of bioactive thieno[3,2-b]pyrrole derivatives and other nitrogen-containing heterocycles relevant to medicinal chemistry.

Synthesis

  • Route1

    References

    • GLAXO GROUP LIMITED Patent: WO2006/65788 A2, 2006 ; Location in patent: Page/Page column 10 ; WO 2006/065788 A2
  • Route2

    References

    • US2010/68178 A1, ; Page/Page column 16-17 ;
  • Route3

    References

    • WO2010/29577 A2, ; Page/Page column 38-39 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   1.1169
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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