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CS-W001157 4
Total: USD 88.00

1,1'-[(1R,3R)-1,3-dimethyl-1,3-propanediyl]bis[1,1-bis[4-(1,1-dimethylethyl)phenyl]-Phosphine

  • CAS No. 1459709-16-0

  • Cat. No. CS-0201557
  • Molecule weight664.92
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,1'-[(1R,3R)-1,3-dimethyl-1,3-propanediyl]bis[1,1-bis[4-(1,1-dimethylethyl)phenyl]-Phosphine|CS-0201557

Structure of 1459709-16-0

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General Information

  • CAS No. 1459709-16-0
  • Cat. No. CS-0201557
  • Purity ≥97%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₅H₆₂P₂
  • Molecular Weight 664.92
  • Synonym(s) Phosphine, 1,1'-[(1R,3R)-1,3-dimethyl-1,3-propanediyl]bis[1,1-bis[4-(1,1-dimethylethyl)phenyl]-
  • SMILES C[C@H](C[C@@H](C)P(C1=CC=C(C(C)(C)C)C=C1)C2=CC=C(C(C)(C)C)C=C2)P(C3=CC=C(C(C)(C)C)C=C3)C4=CC=C(C(C)(C)C)C=C4

Description

This sterically shielded phosphine ligand features two electron-rich aryl groups flanking a rigid, chiral propanediyl backbone, enabling stable coordination in palladium-catalyzed cross-coupling reactions under standard conditions.

Application

1,1'-[(1R,3R)-1,3-dimethyl-1,3-propanediyl]bis[1,1-bis[4-(1,1-dimethylethyl)phenyl]-phosphine] functions as a sterically hindered, bench-stable phosphine ligand that enables efficient transition-metal-catalyzed cross-coupling reactions. Its bulky aryl substituents provide strong electron donation and enhance catalyst stability, facilitating reliable coupling in palladium- and nickel-mediated processes. The ligand exhibits excellent functional group tolerance and simplifies purification due to its high thermal and oxidative stability.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   11.6093
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   8

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