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CS-W001157 4
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1-(5-Bromopyrimidin-2-yl)ethan-1-ol

  • CAS No. 1459771-55-1

  • Cat. No. CS-0169408
  • Molecule weight203.04
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(5-Bromopyrimidin-2-yl)ethan-1-ol|CS-0169408

Structure of 1459771-55-1

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General Information

  • CAS No. 1459771-55-1
  • Cat. No. CS-0169408
  • Purity ≥95%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BrN₂O
  • Molecular Weight 203.04
  • Synonym(s) None
  • SMILES OC(C)C1=NC=C(Br)C=N1

Description

1-(5-Bromopyrimidin-2-yl)ethan-1-ol features a brominated pyrimidine core paired with a pendant hydroxymethyl group, enabling direct incorporation into nucleoside analogs and bioactive heterocycles. This bench-stable reagent offers high functional group compatibility and facilitates efficient coupling reactions under standard conditions.

Application

1-(5-Bromopyrimidin-2-yl)ethan-1-ol serves as a versatile building block for constructing pyrimidine-based scaffolds in medicinal chemistry. Its bromine substituent enables palladium-catalyzed cross-coupling reactions, while the pendant hydroxyl group offers opportunities for derivatization or protection. The compound exhibits good bench stability and facilitates efficient incorporation into heterocyclic frameworks relevant to kinase inhibitors and antiviral agents.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   1.2924
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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