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Structure of 1463-17-8
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2,8-Dimethylquinoline is a sterically hindered quinoline derivative featuring methyl groups at the 2- and 8-positions, enhancing its stability and solubility in organic media. This configuration imparts unique electronic properties, making it valuable for ligand design in transition metal catalysis and as a building block in functional materials synthesis.
2,8-Dimethylquinoline serves as a versatile scaffold in medicinal chemistry and catalysis, offering enhanced solubility and electronic tuning compared to parent quinoline. Its methyl groups stabilize the heterocyclic core and facilitate functionalization at C3 or C4 positions. The compound functions effectively as a ligand in transition metal catalysis and enables direct C–H arylation or palladium-catalyzed coupling reactions under standard conditions. Bench-stable and amenable to purification by column chromatography, it supports scalable synthesis of bioactive molecules and advanced catalyst systems.
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: