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Structure of 146954-76-9
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N-Benzoyl-2′-deoxy-2′-fluorocytidine features a fluorinated sugar moiety that enhances nucleic acid stability and resistance to enzymatic degradation. The benzoyl group at the N4 position provides steric protection and improves solubility in organic solvents. This compound serves as a key building block for synthesizing modified oligonucleotides with enhanced bioavailability and nuclease resistance, particularly in antisense and siRNA applications.
N-Benzoyl-2′-deoxy-2′-fluorocytidine serves as a key nucleoside building block for the synthesis of antiviral agents and oligonucleotide therapeutics. The 2′-fluoro substitution enhances metabolic stability and nuclease resistance, while the N-benzoyl group provides orthogonal protection during phosphoramidite coupling. This derivative exhibits excellent bench stability, facilitates efficient solid-phase synthesis, and enables site-specific incorporation into DNA strands with improved duplex affinity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: