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CS-W001157 4
Total: USD 88.00

(3-Methyl-3H-diazirin-3-yl)methanol

  • CAS No. 14757-55-2

  • Cat. No. CS-0101345
  • Molecule weight86.09
  • Purity≥97%
  • MDL No.MFCD28400864

*For research and further manufacturing use only, not for direct human use.

(3-Methyl-3H-diazirin-3-yl)methanol|CS-0101345

Structure of 14757-55-2

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General Information

  • CAS No. 14757-55-2
  • Cat. No. CS-0101345
  • Purity ≥97%
  • MDL No. MFCD28400864
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₆N₂O
  • Molecular Weight 86.09
  • Synonym(s) 3-Methyl-3H-Diazirine-3-Methanol
  • SMILES OCC1(C)N=N1

Description

This photoreactive reagent features a highly reactive diazirine ring fused to a methanol group, enabling efficient covalent labeling upon UV activation. The pendant hydroxyl group enhances water solubility and facilitates conjugation, while the diazirine moiety delivers stable, site-specific protein crosslinking under standard bench conditions.

Application

(3-Methyl-3H-diazirin-3-yl)methanol serves as a stable, bench-compatible photolabile crosslinking agent that enables site-specific protein–ligand and protein–protein interaction studies. Its trifluoromethyl-substituted diazirine ring undergoes efficient UV-induced activation to generate reactive carbenes, facilitating covalent labeling under physiological conditions. The molecule exhibits good functional group tolerance, mild reaction kinetics, and simplifies purification due to its low molecular weight and hydrophilic character, making it ideal for use in proteomic screening and target identification workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H302-H315-H319-H335
Precautionary Statements : P210-P261-P280-P501

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Computational Chemistry Data

  • TPSA   44.95
  • LogP   0.1607
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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