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Structure of 14757-55-2
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This photoreactive reagent features a highly reactive diazirine ring fused to a methanol group, enabling efficient covalent labeling upon UV activation. The pendant hydroxyl group enhances water solubility and facilitates conjugation, while the diazirine moiety delivers stable, site-specific protein crosslinking under standard bench conditions.
(3-Methyl-3H-diazirin-3-yl)methanol serves as a stable, bench-compatible photolabile crosslinking agent that enables site-specific protein–ligand and protein–protein interaction studies. Its trifluoromethyl-substituted diazirine ring undergoes efficient UV-induced activation to generate reactive carbenes, facilitating covalent labeling under physiological conditions. The molecule exhibits good functional group tolerance, mild reaction kinetics, and simplifies purification due to its low molecular weight and hydrophilic character, making it ideal for use in proteomic screening and target identification workflows.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H225-H302-H315-H319-H335
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Precautionary Statements : P210-P261-P280-P501
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Lot numbers can be found on the outside label of a product: