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CS-W001157 4
Total: USD 88.00

AD-mix-β

  • CAS No. 148618-32-0

  • Cat. No. CS-0131722
  • Molecule weight778.98
  • Purity97%mix
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

AD-mix-β|CS-0131722

Structure of 148618-32-0

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General Information

  • CAS No. 148618-32-0
  • Cat. No. CS-0131722
  • Purity 97%mix
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₈H₅₄N₆O₄
  • Molecular Weight 778.98
  • Synonym(s) Hydroquinidine 1,4-phthalazinediyl ether mixture
  • SMILES [H][C@@]12C[C@]([N@](C[C@@H]2CC)CC1)([H])[C@@H](OC3=NN=C(O[C@@H](C4=CC=NC5=CC=C(C=C45)OC)[C@@]6([H])C[C@@]7([H])[C@@H](CC)C[N@@]6CC7)C8=C3C=CC=C8)C9=CC=NC%10=CC=C(OC)C=C%109

Description

AD-mix-β delivers a highly enantioselective catalyst system for asymmetric dihydroxylation, featuring a chiral quaternary ammonium salt that enables efficient conversion of alkenes to syn-diols under mild conditions. This bench-stable reagent streamlines access to chiral building blocks in natural product synthesis and pharmaceutical development workflows.

Application

AD-mix-β enables highly enantioselective asymmetric dihydroxylation of alkenes, serving as a robust catalyst system for the synthesis of chiral 1,2-diols. Its iron-based catalytic core, combined with a chiral ligand, provides excellent stereoselectivity across a broad range of substrates, including styrenes and electron-deficient alkenes. The reagent exhibits bench stability, ease of handling, and compatibility with standard purification protocols, making it a practical choice for scalable synthesis of pharmaceutical intermediates and natural product building blocks.

Safety Information

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GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335-H411
Precautionary Statements : P261-P264-P271-P273-P302+P352

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Computational Chemistry Data

  • TPSA   94.96
  • LogP   9.2244
  • H_Acceptors   10
  • H_Donors   0
  • Rotatable_Bonds   12

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