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Structure of 3144-09-0
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Methanesulfonamide is used in the synthesis of important organic reagents such as N-(2-methylthio-1-p-toluenesufonyl)methanesulfonamide and tert-butyl ((2-(trimethylsilyl)ethyl)sulfonyl)carbamate.It can be used as a source of nitrogen in the conversion of carboxylic acids to corresponding nitriles.It is widely used as a reagent in the synthesis of medicinally important compounds such as derivatives of indole-N-acetamide, methanesulfonamide pyrimidine-substituted 3,5-dihydroxy-6-heptenoates and repertaxin.
Methanesulfonamide serves as a stable, bench-ready sulfonamide source for amine incorporation in medicinal chemistry and process synthesis. Its high functional group tolerance enables direct use in nucleophilic substitution, amide coupling, and heterocycle formation. The methanesulfonyl group facilitates selective deprotection and acts as a reliable leaving group in cross-coupling reactions. Widely employed in API development, it functions effectively in both solution-phase and solid-phase workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: