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CS-W001157 4
Total: USD 88.00

4-(Methylamino)phenol

  • CAS No. 150-75-4

  • Cat. No. CS-0446965
  • Molecule weight123.15
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Methylamino)phenol|CS-0446965

Structure of 150-75-4

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General Information

  • CAS No. 150-75-4
  • Cat. No. CS-0446965
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO
  • Molecular Weight 123.15
  • Synonym(s) p-Methylaminophenol
  • SMILES CNC1=CC=C(C=C1)O

Description

4-(Methylamino)phenol is a bench-stable, electron-rich arylamine featuring a para-substituted amino group that enhances nucleophilicity and redox activity. This compound integrates readily into conjugated systems and serves as a key intermediate in the synthesis of functional dyes, pharmaceuticals, and advanced materials.

Application

4-(Methylamino)phenol serves as a key building block in the synthesis of pharmaceutical intermediates and functionalized aromatic compounds. Its dual phenolic and primary amine functionalities enable diverse coupling reactions, including Ullmann-type C–N bond formations and electrophilic substitutions. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in medicinal chemistry campaigns requiring modular heterocyclic scaffold construction.

Synthesis

  • Route1
    • null|null
      123-30-8
    • null|null
      616-38-6
    • ~91%
    • In-stock
      4-(Methylamino)phenol|CS-0446965
      150-75-4

    References

    • Consorzio Interuniversitario Nazionale "La Chimica Per L'Ambiente" Patent: EP1431274 A1, 2004 ; Location in patent: Page 5 ;
  • Route2

    References

    • Blanco, Victor; Leigh, David A.; Marcos, Vanesa; Morales-Serna, Jose A.; Nussbaumer, Alina L. Journal of the American Chemical Society, 2014 , vol. 136, # 13 p. 4905 - 4908
  • Route3
    • null|null
      123-31-9
    • null|null
      74-89-5
    • ~%
    • In-stock
      4-(Methylamino)phenol|CS-0446965
      150-75-4

    References

    • Kodak A.G. Patent: DE631462 , 1934 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 216

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08,GHS09
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H332-H341-H410
Precautionary Statements : P261-P264-P270-P271-P273-P304+P340-P330-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   1.4339
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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