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CS-W001157 4
Total: USD 88.00

1-Cyclopropyl-2-(2-fluorophenyl)ethanone

  • CAS No. 150322-73-9

  • Cat. No. CS-0037683
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Cyclopropyl-2-(2-fluorophenyl)ethanone|CS-0037683

Structure of 150322-73-9

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General Information

  • CAS No. 150322-73-9
  • Cat. No. CS-0037683
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁FO
  • Molecular Weight 178.20
  • Synonym(s) Cyclopropyl 2-fluorobenzylketone
  • SMILES C1=CC=C(C(=C1)CC(=O)C2CC2)F

Description

1-Cyclopropyl-2-(2-fluorophenyl)ethanone features a fluorinated aromatic ring paired with a cyclopropyl ketone moiety, enabling enhanced metabolic stability and favorable lipophilic character. This scaffold integrates readily into bioactive molecules, particularly in medicinal chemistry campaigns targeting CNS disorders and kinase inhibition, where its steric profile and electronic modulation support improved target engagement.

Application

1-Cyclopropyl-2-(2-fluorophenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its aryl ketone functionality supports standard transformations including nucleophilic additions, reductions, and coupling reactions. The cyclopropyl group enhances metabolic stability and modulates lipophilicity, while the ortho-fluorophenyl moiety provides favorable electronic and steric properties for target engagement. This compound exhibits bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1
    • null|null
      446-48-0
    • null|null
      5500-21-0
    • ~71%
    • In-stock
      1-Cyclopropyl-2-(2-fluorophenyl)ethanone|CS-0037683
      150322-73-9

    References

    • TORRENT PHARMACEUTICALS LTD. Patent: WO2009/122440 A1, 2009 ; Location in patent: Page/Page column 31 ;
  • Route2
    • 2-(2-Fluorophenyl)-N-methoxy-N-methylacetamide|CS-0554515
      946402-23-9
    • null|null
      4333-56-6
    • ~%
    • In-stock
      1-Cyclopropyl-2-(2-fluorophenyl)ethanone|CS-0037683
      150322-73-9

    References

    • WO2011/42918 A2, ; Page/Page column 49-50 ;
  • Route3
    • null|null
      5500-21-0
    • ~%
    • In-stock
      1-Cyclopropyl-2-(2-fluorophenyl)ethanone|CS-0037683
      150322-73-9

    References

    • US2007/243243 A1, ; Page/Page column 20 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.3473
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

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