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CS-W001157 4
Total: USD 88.00

6-Chloro-5-iodoindolin-2-one

  • CAS No. 1507976-00-2

  • Cat. No. CS-0160550
  • Purity≥95%
  • MDL No.MFCD24115710

*For research and further manufacturing use only, not for direct human use.

6-Chloro-5-iodoindolin-2-one|CS-0160550

Structure of 1507976-00-2

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General Information

  • CAS No. 1507976-00-2
  • Cat. No. CS-0160550
  • Purity ≥95%
  • MDL No. MFCD24115710
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClINO
  • Molecular Weight 293.49
  • Synonym(s) 6-Chloro-5-iodo-1,3-dihydro-2H-indol-2-one
  • SMILES O=C1NC2=C(C=C(I)C(Cl)=C2)C1

Description

6-Chloro-5-iodoindolin-2-one features a sterically constrained indolinone core with complementary halogen substituents enabling selective cross-coupling. The chlorine and iodine atoms facilitate sequential functionalization, while the lactam carbonyl enhances solubility and reactivity in transition-metal-catalyzed transformations under standard conditions.

Application

6-Chloro-5-iodoindolin-2-one serves as a versatile building block for the synthesis of substituted indoles and heterocyclic scaffolds. The ortho-halogenated structure enables palladium-catalyzed cross-coupling reactions, facilitating efficient C–C bond formation under standard conditions. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   2.4392
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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