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Structure of 1514-96-1
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4-Chloro-2-(trifluoromethyl)pyrimidine serves as a pivotal heterocyclic scaffold in medicinal chemistry, featuring a chlorine atom at C4 and a trifluoromethyl group at C2. This combination imparts enhanced metabolic stability and favorable lipophilicity, enabling efficient incorporation into kinase inhibitors and antiviral agents. The electron-deficient pyrimidine ring facilitates nucleophilic substitution reactions under mild conditions, streamlining downstream functionalization.
4-Chloro-2-(trifluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient C–N and C–C coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloropyrimidine moiety facilitates nucleophilic substitution under mild conditions. The compound exhibits excellent bench stability and compatibility with diverse functional groups, making it ideal for constructing heterocyclic scaffolds in drug discovery workflows.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
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Lot numbers can be found on the outside label of a product: