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Structure of 1582-25-8
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4-Chloro-6-methyl-2-trifluoromethylpyrimidine features a trifluoromethyl group at the 2-position and a methyl substituent at the 6-position, conferring enhanced electron-withdrawing character and metabolic stability. This pyrimidine scaffold serves as a key building block in agrochemical and pharmaceutical synthesis, offering high reactivity in cross-coupling and nucleophilic substitution reactions under standard conditions.
4-Chloro-6-methyl-2-trifluoromethylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloro and methyl substituents provide orthogonal sites for nucleophilic substitution and further functionalization. The compound exhibits good bench stability and compatibility with standard cross-coupling and amine displacement reactions, facilitating rapid diversification in API discovery workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: