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CS-W001157 4
Total: USD 88.00

2-Bromopyrazolo[1,5-a]pyridine

  • CAS No. 1520497-11-3

  • Cat. No. CS-0311088
  • Molecule weight197.03
  • Purity≥97%
  • MDL No.MFCD32066291

*For research and further manufacturing use only, not for direct human use.

2-Bromopyrazolo[1,5-a]pyridine|CS-0311088

Structure of 1520497-11-3

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General Information

  • CAS No. 1520497-11-3
  • Cat. No. CS-0311088
  • Purity ≥97%
  • MDL No. MFCD32066291
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrN₂
  • Molecular Weight 197.03
  • Synonym(s) None
  • SMILES BrC1=NN2C=CC=CC2=C1

Description

2-Bromopyrazolo[1,5-a]pyridine is a heterocyclic building block featuring a brominated pyrazolopyridine core. This scaffold enables direct functionalization in cross-coupling reactions and serves as a key intermediate in medicinal chemistry. The electron-deficient aromatic system enhances reactivity in palladium-catalyzed transformations, while the bromine substituent offers precise handle for further diversification. Stable under standard handling conditions.

Application

2-Bromopyrazolo[1,5-a]pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to construct biologically relevant heterocyclic architectures. Its bromine substituent facilitates reliable C–C and C–heteroatom bond formation under standard conditions, while the fused pyrazolo[1,5-a]pyridine core offers enhanced metabolic stability and favorable π-stacking properties. The compound exhibits excellent bench stability and compatibility with diverse functional groups, making it ideal for modular synthesis of kinase inhibitors and other target-oriented scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.3
  • LogP   2.0968
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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