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tert-Butyl 2,5-diazaspiro[3.5]nonane-5-carboxylate oxalate(2:1)

  • CAS No. 1523571-07-4

  • Cat. No. CS-0048446
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2,5-diazaspiro[3.5]nonane-5-carboxylate oxalate(2:1)|CS-0048446

Structure of 1523571-07-4

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General Information

  • CAS No. 1523571-07-4
  • Cat. No. CS-0048446
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₆H₄₆N₄O₈
  • Molecular Weight 542.67
  • Synonym(s) 5-Boc-2,5-diazaspiro[3.5]nonane hemioxalate - B7351
  • SMILES OC(=O)C(O)=O.CC(C)(C)OC(=O)N1CCCCC11CNC1.CC(C)(C)OC(=O)N1CCCCC11CNC1

Description

tert-Butyl 2,5-diazaspiro[3.5]nonane-5-carboxylate oxalate (2:1) features a spirocyclic diamine core with orthogonal protection, enabling straightforward deprotection and functionalization. The oxalate salt enhances solubility and stability in polar solvents, facilitating use in peptide coupling and medicinal chemistry applications.

Application

tert-Butyl 2,5-diazaspiro[3.5]nonane-5-carboxylate oxalate (2:1) serves as a stable, bench-ready spirocyclic diamine building block with orthogonal protection. The tert-butyl carbamate group enables mild deprotection under acidic conditions, while the oxalate counterion enhances solubility and crystallinity. It facilitates efficient access to complex nitrogen-containing scaffolds via standard coupling reactions, reductive amination, or transition-metal-catalyzed transformations, making it valuable for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   157.74
  • LogP   2.6544
  • H_Acceptors   8
  • H_Donors   4
  • Rotatable_Bonds   0

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